Explore PA Regions
From Pittsburgh to Philadelphia—and everywhere in between—Pennsylvania’s six distinct regions offer growing businesses a powerful combination of robust workforce pipelines, strong interconnectivity with key markets, and deep ecosystems of support designed to help companies achieve their ambitions for growth.
Southwest Pennsylvania is advancing robotics, energy, and advanced manufacturing innovation, while Southeast Pennsylvania has become a major hub for life sciences and corporate investments. The Lehigh Valley continues to thrive as a national center for manufacturing and logistics, while Central Pennsylvania, Northeast Pennsylvania, and Northwest Pennsylvania are home to class-leading companies in agriculture, food production, advanced and industrial manufacturing, and more. Across each region, residents enjoy a high quality of life defined by affordable living, vibrant communities, and easy access to outdoor recreation, arts, culture, and entertainment.
Together, Pennsylvania’s regions form a highly connected statewide economy that offers businesses the resources, talent, and market access needed to compete and grow globally. Browse each region below to find the best fit for your business—then connect with BusinessPA to explore resources and support for your company’s next phase of growth.
Central Pennsylvania
Stretching across the heart of the Commonwealth, Central Pennsylvania combines convenient East Coast access with a diverse economic landscape, supporting businesses big and small across core sectors like advanced manufacturing, agriculture and energy. From Harrisburg and Hershey to Lancaster, York, and Gettysburg, the region offers companies and their workers opportunities for growth in an environment with a competitive cost of living and a high quality of life.
Northeast Pennsylvania
Northeast Pennsylvania is your company's gateway to the East Coast, providing direct access to New York, Philadelphia, and beyond—without paying East Coast prices. A thriving base of manufacturers across diverse sectors—from defense to food production—and a strong regional logistics network continue to attract businesses seeking efficiency, affordability, and room to grow.
Lehigh Valley
The Lehigh Valley has emerged as one of the fastest-growing economic regions in the Northeast, leveraging its industrial legacy to fuel innovation and economic diversification. Home to globally recognized manufacturers and life sciences innovators, the region also houses a strong pipeline of universities and workforce training programs, providing a steady stream of talent for nearby employers.
Southeast Pennsylvania
Southeast Pennsylvania blends a world-class innovation ecosystem with a large presence of cutting-edge companies across life sciences, advanced manufacturing, and technology. Anchored by Philadelphia and supported by a dense network of universities, research institutions, and globally recognized companies, the region offers businesses unparalleled access to talent, innovation, and growth opportunities.
Southwest Pennsylvania
Who needs Silicon Valley? Southwest Pennsylvania is one of the nation's top hubs for robotics, artificial intelligence, energy innovation, and advanced manufacturing, home to companies building the cutting-edge of what's next. Centered around Pittsburgh’s robust innovation ecosystem and supported by a strong network of university talent and research, the region has become a destination for creative companies who want to operate in region filled with opportunity.
Northwest Pennsylvania
Northwest Pennsylvania’s economy is built on generations of manufacturing expertise, strengthened today by innovation in plastics, powdered metals, and varied manufacturing. With access to key interstate corridors, Great Lakes shipping, and major U.S. and Canadian markets, the region provides companies with the infrastructure and workforce needed to grow their operations.
Harrisburg (Central Region)
Erie (Northwest Region)
Scranton (Northeast Region)
Allentown (Lehigh Valley)
Philadelphia (Southeast Region)
Pittsburgh (Southwest Region)
- Central
- Northwest
- Northeast
- Lehigh Valley
- Southeast
- Southwest
We would encourage anyone who's looking to start a business or looking to grow their business and need a new place for a corporate headquarters... you really should look at Pennsylvania."
— Edward Stack, Executive Chairman, DICK'S Sporting Goods (Allegheny County)